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. 2019 Oct 22;18(23):3251–3262. doi: 10.1080/15384101.2019.1673099

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Figure 5. — Repression of CXCL14 gene expression is relevant to IRX1.

(A-B) CXCL14 mRNA and protein expression was downregulated in TAC rats. Data are presented as the mean ± SD of five animals; **P < 0.01, vs. Sham-Normal group, # P < 0.05, vs. TAC-Normal group. (C) The effect of IRX1-targeting shRNAs was confirmed by western blot analysis. (D) The efficiency of IRX1 overexpression was confirmed by Western blot analysis. (E) CXCL14 mRNA levels were downregulated by IRX1 shRNA transfection. Data are presented as the mean ± SD, ***P < 0.001 (F) CXCL14 mRNA levels were upregulated by IRX1 overexpression. Data are presented as the mean ± SD, ***P < 0.001 (G-H) CXCL14 protein levels were downregulated by IRX1 shRNA transfection and upregulated by IRX1 over expression. Data are presented as the mean ± SD, ***P < 0.001, vs. ShCtrl group, ## P < 0.01 vs. Vector group.