Figure 3.

Restoration of miR-223 expression suppressed BC growth in vivo. (a, b) T24 (a) or SW780 (b) cells were transfected with miR-223 mimic or miR-223 inhibitor, respectively. Then, these cells were injected into nude mice. Tumor growth curves were measured after injection. (c) Representative pictures of tumors formed. (d) Immunohistochemical staining demonstrated that the overexpression of miR-223 in T24 cells (upper panel) inhibits, while the suppression of miR-223 in SW780 cells (bottom panel) induces tumor growth in vivo, as indicated by the expression of Ki-67. (e) SW780 cells were transfected with miR-223 mimic or control mimic. Then, these cells were injected into nude mice. Tumor growth curves were measured after injection. *P < 0.05.