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. 2019 Nov 22;19(1):67–83. doi: 10.1080/15384101.2019.1693118

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This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.

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Figure 4. — Ingenuity Pathways that met a p-value cutoff of p ≤ 0.005 in WT cells: comparison of WT response to the remaining 6 genotypes. The Ingenuity Canonical Pathway -log10 (p-values) generated for each genotype were compared for the 64 pathways that were significantly over-represented in WT cells based on a p-value of ≤ 0.005 (= -log10 (p-value) of 2.3). The -log10 (p-values) were clustered to determine the similarities and differences between the 7 genotypes based on the WT response to IR.