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. 2019 Nov 18;18(24):3589–3602. doi: 10.1080/15384101.2019.1693120

Figure 6.

Figure 6.

Role of ETS1 in the TGF-β induced PXR expression. (a) Immunoblot analysis of phospho-ETS1 and ETS1 in HepG2 cells sensitized with recombinant TGF-β alone or in combination with PD98059. (b) qRT-PCR of ETS1 in control and ETS1 knockdown HepG2 cells. (c) Immunoblot analysis of PXR expression in control and ETS1 knockdown HepG2 cells in the presence or absence of recombinant TGF-β. (d) Chip analysis of ETS1 binding at PXR promoter in the presence and absence of recombinant TGF-β. Asterisks represent significant differences (*p < 0.05, **p < 0.005, ***p < 0.0005). Data are representative of three independent experiments performed in triplicate.