Table 3. Antibody sequence characteristics from patient 013 unstimulated and stimulated PBMCs related to clonal families of single plasmablasts with reactivity to DENV.
| Clonal family (antibodies) |
Germline | Isotype | Reads for all clonotypes | |
|---|---|---|---|---|
| Unstimulated | Stimulated | |||
| 10 | IGHV3-30-3 | Total | 143 | 216292 |
| (C1, A7, I11, L9, P2, G5) | IgM | 8 | 427 | |
| IgG | 112 | 199151 | ||
| IgA | 23 | 16714 | ||
| 5 | IGHV1-69 | total | 422 | 141308 |
| (C4, J2, N2) | IgM | 9 | 91 | |
| IgG | 413 | 140117 | ||
| IgA | 0 | 1100 | ||
| 13 | IGHV4-34 | total | 32 | 82814 |
| (N8, F4) | IgM | 0 | 195 | |
| IgG | 32 | 76605 | ||
| IgA | 0 | 6014 | ||
| 7 | IGHV1-69 | total | 579 | 43179 |
| (J8, J9) | IgM | 10 | 98 | |
| IgG | 568 | 42315 | ||
| IgA | 1 | 764 | ||
| 9 | IGHV1-69 | total | 673 | 35793 |
| (K11, L3, M4, M11, O4) | IgM | 12 | 103 | |
| IgG | 656 | 34444 | ||
| IgA | 5 | 1246 | ||
| 8 | IGHV1-69 | total | 10 | 7349 |
| (J3, 403_P4) | IgM | 0 | 16 | |
| IgG | 10 | 7001 | ||
| IgA | 0 | 332 | ||
| 3 | IGHV1-18 | total | 10 | 2993 |
| (405_P4, I13) | IgM | 1 | 6 | |
| IgG | 9 | 2899 | ||
| IgA | 0 | 88 | ||
| 1 | IGHV4-39 | total | 4 | 1087 |
| (B10, M1, D8) | IgM | 1 | 11 | |
| IgG | 3 | 1049 | ||
| IgA | 0 | 27 | ||
| 2 | IGHV1-69 | total | 0 | 1087 |
| (H3, M6) | IgM | 0 | 7 | |
| IgG | 0 | 1066 | ||
| IgA | 0 | 14 | ||
| 11 | IGHV3-30-3 | total | 0 | 19 |
| (E9, I8) | IgM | 0 | 0 | |
| IgG | 0 | 19 | ||
| IgA | 0 | 0 | ||