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. 2019 Dec 18;12(1):1699768. doi: 10.1080/19420862.2019.1699768

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Logistic regression analysis of exposure-efficacy (ORR) response relationship by acMMAE AUC_inf at Cycle 1.

The black line and shaded gray area represent logistic regression model prediction and 90% confidence interval of predictions, open circle show exposure of individual patients with event (p = 1) and without events (p = 0), black solid circle and vertical lines show observed fraction of subjects with events in each exposure quartile and 90% confidence interval for these fractions. acMMAE: antibody-conjugated MMAE, AUC_inf: area under the concentration–time curve from time zero to infinity, ADC1 = Pinatuzumab vedotin (CD22); ADC2 = Polatuzumab vedotin (CD79b); ADC3 = DEDN6526A (ETBR); ADC6 = DNIB0600A (Napi2b); iNHL = indolent non-Hodgkin’s Lymphomas; DLBCL = diffuse large B-cell lymphoma.