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Observed and individual model fitted profiles for anti-EGFR CAR-T induced tumor growth inhibition. Intracranial xenograft mice, inoculated with EGFR-expressing U87 cells (Day 0), were treated with intratumoral (IT) administration of (1) PBS vehicle control (profiles in black), (2) 1 million high-affinity cetuximab CAR-T cells (profiles in red) and (3) 1 million low-affinity nimotuzumab CAR-T cells (profiles in blue) in a Q1WX3 dosing regimen, starting at day 4.
