Table 1.

Glycation sites identified by top-down and middle-down MALDI-ISD FT-ICR MS, and standard bottom-up LC-MS/MS.

		Glycated sites
Top-down MS	Hc1	K12
	Hc2	R19
Middle-down MS	(Fc/2)1 and (Fc/2)2	K262 on (Fc/2)1 or K252 on (Fc/2)2
Bottom-up LC-MS/MS with HCD	Lc1	N-terminus Q1; K30
	Lc2	K45; K126; K149; K169; K190
	Hc1	K23; K171; K191; K212; K238; 342; K376
	Hc2	N-terminus E1; K43; K76; K228; K332
Bottom-up LC-MS/MS with ETD	Hc1	K63; K171; K205; K304; K333; K342; K350; K425
	Hc2	K43; K76; K139; K294; K323; K332; K340; K415