. 2018 May 22;73(8):2072–2077. doi: 10.1093/jac/dky162

Table 3.

MIC range and MIC₅₀ of gepotidacin and ciprofloxacin for N. gonorrhoeae isolates (n = 21) with a D86N mutation in the QRDR of ParC combined with other GyrA and ParC QRDR mutations

Mutation pattern (no.)	Gepotidacin		Ciprofloxacin
Mutation pattern (no.)	MIC range	MIC₅₀	MIC range	MIC₅₀
ParC D86N, GyrA S91F + D95G (14)	1–4	2	4 to >32	8
ParC D86N, GyrA S91F + D95A (5)	0.5–1	1	1–8	2
ParC D86N + S88P, GyrA S91F + D95N (1)	4	not applicable	>32	not applicable
ParC D86N, GyrA S91F + D95N (1)	2	not applicable	8	not applicable

MICs (mg/L) were determined by agar dilution for gepotidacin and Etest for ciprofloxacin.