Table 2.

Sensitivity and specificity of individual studies for which meta-analysis was not performed because of non-converging data

TPS Cut-off	Gold Standard Assay	Candidate Assay	Author	Year	Tumor Type*	Sample Size	Sensitivity	Specificity
50%	PD-L1 IHC 22C3 pharmDx	22C3 LDT	Ilie et al.	2018	L	120	1.00	1.00
			Ilie et al	2017	L	120	1.00	1.00
			Røge et al.	2017	L	75	0.93	1.00
			Røge et al.	2017	L	75	1.00	1.00
			Neuman et al.	2016	L	41	1.00	1.00
			Ilie et al.	2018	L	120	1.00	1.00
			Røge et al.	2017	L	75	1.00	1.00
			Ilie et al	2017	L	120	1.00	1.00
			Neuman et al.	2016	L	41	1.00	1.00
			Munari et al.	2018	L	183	0.85	0.97
			Hendry et al.	2018	L	551	0.84	1.00
50%	Ventana PD-L1 (SP263)	Ventana PD-L1 (SP142)	Adam et al.	2018	L	41	0.19	1.00
			Adam et al.	2018	L	41	0.11	1.00
			Adam et al.	2018	L	41	0.19	1.00
			Adam et al.	2018	L	41	0.11	1.00
			Chan et al.	2018	L	713	0.67	1.00
			Fujimoto et al.	2017	L	40	0.33	1.00
			Scheel et al.	2016	L	135	0.54	1.00
			Soo et al.	2018	L	18	0.33	1.00
			Tretiakova et al.	2018	U	161	0.46	0.96
			Kim et al.	2017	L	97	0.00	1.00
			Cheung et al.	2019	L	54	0.60	1.00
			Hendry et al.	2018	L	355	0.33	1.00
			Tsao et al.	2018	L	81	0.28	1.00
1%	Ventana PD-L1 (SP263)	28-8 LDT	Adam et al.	2018	L	41	0.70	1.00
			Adam et al.	2018	L	41	0.73	1.00
			Adam et al.	2018	L	41	0.76	1.00
			Adam et al.	2018	L	41	0.67	0.93
50%	Ventana PD-L1 (SP263)	28-8 LDT	Adam et al.	2018	L	41	1.00	0.81
			Adam et al.	2018	L	41	1.00	0.76
			Adam et al.	2018	L	41	0.82	0.67
			Adam et al.	2018	L	41	1.00	0.70
1%	PD-L1 IHC 22C3 pharmDx	28-8 LDT	Adam et al.	2018	L	41	0.66	1.00
			Adam et al.	2018	L	41	0.63	1.00
			Adam et al.	2018	L	41	0.68	1.00
			Adam et al.	2018	L	32	0.70	1.00
			Adam et al.	2018	L	32	0.67	1.00
			Adam et al.	2018	L	32	0.73	1.00

* L NSCLC, U UC