Table 2.
Characterization of liposomes before freeze-drying and after freeze-drying with addiction of sucrose.
| Before freeze-drying | After freeze-drying | ||||||
|---|---|---|---|---|---|---|---|
| Encapsulated drug | Z-average (d.nm) | PDI | Encapsulation efficiency (%) | Drug:lipid (molar ratio) | Z-average (d.nm) | PDI | Leakage (%) |
| (-) | 125.5 ± 4.3 | 0.068 ± 0.036 | - | - | 154.3 ± 1.9 | 0.135 ± 0.009 | - |
| MTX | 126.5 ± 3.5 | 0.078 ± 0.008 | 2.6 ± 0.1 | ~1:11 | 166.5 ± 4.1 | 0.165 ± 0.053 | 61.1 ± 4.0 |
| DOX | 134.1 ± 0.5 | 0.111 ± 0.018 | 65.3 ± 1.4 | ~1:11 | 169.1 ± 3.4 | 0.200 ± 0.012 | 24.5 ± 0.3 |
| TAM | 107.8 ± 1.4 | 0.036 ± 0.003 | 93.9 ± 6.1 | ~1:11 | 148.5 ± 4.4 | 0.130 ± 0.020 | 4.0 ± 3.0 |
Values represent the mean ± SD of 3 independent experiments.