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. 2019 Dec 17;10:2877. doi: 10.3389/fmicb.2019.02877

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Copyright © 2019 Lee, Im, Na, Ryu, Yun and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Polymorphism in the variable region of PIP_EF in E. faecalis strains is related with phage HEf13 host specificity. (A) Multiple amino acid sequence alignment of the PIP_EF variable region in 17 strains of E. faecalis was generated by Geneious 6.0.5 software. Difference in amino acid sequence of E. faecalis strains is presented in different colors. (B) Phylogenetic tree of PIP_EF homologs was constructed by Neighbor-joining method with 1,000 replicates. Scale bar represents a 10% difference in sequence similarity between homologs. Strains are indicated by color as follows: clear-plaque-forming strain (red), turbid-plaque-forming strains (blue), and phage-resistant strains (black).