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. 2019 Dec 17;10:1445. doi: 10.3389/fphys.2019.01445

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Copyright © 2019 Weng, Wu, Kao, Chen and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A schematic representation of the role of miR-34a-5p in the function of ADSCs in the mouse MI model. miR-34a-5p targets and negatively regulates the expression of CTRP9. Up-regulated CTRP9 could enhance the proliferation and migration of ADSCs by increasing the expression of ERK1, MMP-9, NRF2, MnSOD and HO-1. Therefore, down-regulation of miR-34a-5p plays a promoting role in the protective effect of ADSCs against MI damage by up-regulating CTRP9. miR-34a-5p, microRNA-34a-5p; ADSCs, adipose-derived stem cells; MI, myocardial infarction; CTRP9, C1q/tumor necrosis factor-related protein-9; MMP-9, matrix metalloproteinase-9; NRF2, nuclear factor (erythroid-derived 2)-like 2; HO-1, heme oxygenase-1.