Figure 10.

Differential expression of T-cell receptors in primary tumors of the 4T1- compared to Py230-based intraductal model. Heatmap displaying expression levels of selected genes involved in co-stimulatory/co-inhibitory T-cell receptors in three independent 4T1 and Py230 primary tumor samples at 1 w p.i. (A), 3 w p.i. (B), and 6 w p.i. (C). (D) Heatmap displaying the log2 fold change in mean gene expression of the selected co-stimulatory/co-inhibitory T-cell receptors in 4T1 and Py230 primary tumor samples at 1, 3, and 6 w p.i. The selection of the T-cell receptor genes was based on the gene list from the NanoString Mouse PanCancer Immune Profiling Panel and a publication by Yu et al. (30). Hierarchical clustering was performed using Pearson distance.