Table 4.
Association of ETS-1 polymorphism with the clinical characteristics of PBC.
| SNPs | Model | Genotype | TP | HDLC | ALP | PLT | RDW | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Median (P25, P75) | P value | Median (P25, P75) | P value | Median (P25, P75) | P value | Median (P25, P75) | P value | Median (P25, P75) | P value | |||
| rs4937333 | CC | 74.10(64.45,79.05) | 1.22(0.66,1.86) | 182.00(121.00,279.25) | 110.00(61.50,182.50) | 15.50(13.70,17.30) | ||||||
| CT | 76.90(72.38,82.58) | 0.065 | 1.59(1.20,1.83) | 0.123 | 165.00(114.00,271.75) | 0.614 | 112.00(80.25,151.25) | 0.910 | 14.70(13.60,15.95) | 0.055 | ||
| TT | 77.20(73.20,82.00) | 1.46(0.98,1.94) | 193.00(136.00,312.00) | 107.00(72.00,177.00) | 14.00(13.10,16.00) | |||||||
| Dominant | CC | 74.10(64.45,79.05) | 1.22(0.66,1.86) | 182.00(121.00,279.25) | 110.00(61.50,182.50) | 15.50(13.70,17.30) | ||||||
| CT + TT | 76.90(72.70,82.10) | 0.020 | 1.53(1.12,1.83) | 0.053 | 171.00(115.00,290.00) | 0.911 | 112.00(77.00,154.00) | 0.813 | 14.40(13.20,15.95) | 0.069 | ||
| Recessive | CC + CT | 76.20(69.78,81.13) | 1.51(1.03,1.83) | 169.50(115.50,271.75) | 111.00(76.00,161.00) | 14.80(13.60,16.50) | ||||||
| TT | 77.20(73.20,82.00) | 0.333 | 1.46(0.98,1.94) | 0.936 | 193.00(136.00,312.00) | 0.382 | 107.00(72.00,177.00) | 0.799 | 14.00(13.10,16.00) | 0.033 | ||
| rs11221332 | CC | 76.20(69.80,80.70) | 1.47(0.98,1.83) | 175.00(114.00,295.00) | 110.00(72.25,155.00) | 14.60(13.40,16.50) | ||||||
| CT | 81.60(76.55,84.55) | 0.012 | 1.77(1.63,1.87) | 0.030 | 165.00(125.00,226.00) | 0.519 | 191.00(90.50,221.50) | 0.133 | 14.60(13.60,15.15) | 0.393 | ||
| TT | 86.30(86.30,86.30) | 3.47(3.47,3.47) | 344.00(344.00,344.00) | 107.00(107.00,107.00) | 13.00(13.00,13.00) | |||||||
| Dominant | CC | 76.20(69.80,80.70) | 1.47(0.98,1.83) | 175.00(114.00,295.00) | 110.00(72.25,155.00) | 14.60(13.40,16.50) | ||||||
| CT + TT | 81.80(77.88,85.40) | 0.004 | 1.79(1.64,2.36) | 0.015 | 171.00(128.00,259.00) | 0.969 | 189.00(93.75,219.75) | 0.056 | 14.60(13.48,14.98) | 0.432 | ||
| Recessive | CC + CT | 76.50(72.00,81.18) | 1.51(1.01,1.83) | 173.00(116.00,282.25) | 111.00(73.00,162.00) | 14.60(13.40,16.35) | ||||||
| TT | 86.30(86.30,86.30) | 0.143 | 3.47(3.47,3.47) | 0.096 | 344.00(344.00,344.00) | 0.264 | 107.00(107.00,107.00) | 0.908 | 13.00(13.00,13.00) | 0.200 | ||
| rs73013527 | CC | 77.10(72.05,81.00) | 1.50(1.04,1.97) | 166.00(105.00,259.00) | 117.50(84.00,172.00) | 14.40(13.28,15.75) | ||||||
| CT | 76.25(70.70,81.70) | 0.845 | 1.60(1.00,1.88) | 0.538 | 175.50(120.75,322.25) | 0.570 | 111.50(75.25,179.50) | 0.010 | 14.50(13.35,16.30) | 0.070 | ||
| TT | 75.60(72.00,82.00) | 1.47(0.83,1.75) | 185.00(121.00,283.00) | 74.00(48.00,170.00) | 16.10(14.10,17.50) | |||||||
| Dominant | CC | 77.10(72.05,81.00) | 1.50(1.04,1.97) | 166.00(105.00,259.00) | 117.50(84.00,172.00) | 14.40(13.28,15.75) | ||||||
| CT + TT | 76.20(71.80,81.80) | 0.581 | 1.53(0.98,1.84) | 0.838 | 180.00(121.00,304.00) | 0.289 | 101.00(66.50,160.50) | 0.195 | 14.60(13.40,16.55) | 0.416 | ||
| Recessive | CC + CT | 76.60(72.00,81.10) | 1.53(1.03,1.88) | 171.00(114.00,285.00) | 116.00(81.50,176.25) | 14.40(13.33,15.90) | ||||||
| TT | 75.60(72.00,82.00) | 0.726 | 1.47(0.83,1.75) | 0.272 | 185.00(121.00,283.00) | 0.697 | 74.00(48.00,170.00) | 0.002 | 16.10(14.10,17.50) | 0.021 | ||
Note: Significant p-values (<0.05) are highlighted in bold.