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. 2019 Dec 23;9:19655. doi: 10.1038/s41598-019-56295-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of QST measurements for rs10166942 between carriers (allele [C]; n = 18) and non-carriers (allele [T]; n = 20) (a,b), and between genotypes (c,d). QST was performed using a Peltier thermode placed against the skin, which was then cooled at a rate of 1 °C per second (until 0 °C). The temperature and time at which the participant experienced the cold pain threshold were recorded. Differences between the groups are represented as means (or medians) with 95% confidence intervals.