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. 2019 Dec 17;13:539. doi: 10.3389/fncel.2019.00539

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Copyright © 2019 Yang, Yang, Zhu, Wei, Li, Cheng, Liu, Wu, Zhang, Zhang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of major synaptic components was not affected in Pcp2-Cre;Rack1^F/F mutant mice. (A) Representative Western blots examining the expression of major postsynaptic components in Rack1^F/F control and Pcp2-Cre;Rack1^F/F mutant cerebellum at postnatal day 21 (P21). (B) Quantitative analysis indicates normal levels of postsynaptic components but reduced level of HDAC2 expression in Pcp2-Cre;Rack1^F/F mutants, ^∗p = 0.0092, n = 3. Reduced expression of Rack1 was confirmed in Pcp2-Cre;Rack1^F/F mutant compared to control littermates. Mean ± SEM, ^∗p = 0.0056, n = 3. The expression of GluA2, TARPr2, and dynamin 1 in mutant mice is not significant compared to control littermates, p = 0.0962, 0.1346, and 0.1125, respectively.