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ZPD-2 inhibits the aggregation of α-synuclein familial variants. (A) Aggregation kinetics of WT (black), H50Q (blue), and A30P (green) variants of α-Syn in presence (dotted) and absence (continuous) of ZPD-2, using Th-T as reporter. (B) End-point measurements of the aggregation of WT, H50Q, and A30P variants of α-Syn in presence (dotted) or absence (continuous) of ZPD-2 Th-T fluorescence are expressed as normalized means. Error bars are shown as standard errors of mean values.
