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. 2019 Dec 17;12:306. doi: 10.3389/fnmol.2019.00306

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Copyright © 2019 Peña-Díaz, Pujols, Conde-Giménez, Čarija, Dalfo, García, Navarro, Pinheiro, Santos, Salvatella, Sancho and Ventura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ZPD-2 blocks the aggregation of two different α-synuclein strains. (A,E) Aggregation kinetics of α-Syn strains B (A) and C (E) in absence (black) and presence (green) of ZPD-2. (B,F) Light scattering final point measurements at 300 nm of untreated (white) and ZPD-2-treated samples (green) of strains B (B) and C (F). (C,D,G,H) Representative TEM images of untreated α-Syn aggregates (C,G) and treated (D,H) samples for strains B and C, respectively. Th-T fluorescence is expressed as normalized means. Final points were obtained at 48 h after the aggregation reaction begins. Error bars are shown as standard errors of mean values, where p < 0.05 and p < 0.001 were indicated by ^∗ and ^∗∗∗, respectively.