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. 2019 Dec 17;10:2913. doi: 10.3389/fimmu.2019.02913

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Copyright © 2019 Doz-Deblauwe, Carreras, Arbues, Remot, Epardaud, Malaga, Mayau, Prandi, Astarie-Dequeker, Guilhot, Demangel and Winter.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CR3-mediated infection by rBCG::PGL-I induces Syk-dependent NF-κb independent cytokines. (A) TNF produced in supernatants of DCs, PMNs or MPs derived from bone marrow of WT mice, treated with DMSO (vehicle), or 1 μM of the Syk inhibitor GS-9973, and itgam^−/− mice was determined by ELISA after overnight infection with the three rBCG strains at MOI of 5 under non-opsonizing conditions (n = 8). (B) IL-2 produced by DCs, IL-10 by PMNs and IL-1β by MPs from WT cells treated with DMSO, or 1 μM of the Syk inhibitor GS-9973 or itgam^−/− or clec7a^−/− cells infected as in (A) were determined by ELISA (n = 4). Data are presented as mean ± SEM. ^**P < 0.01; ^***P < 0.001.