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. 2019 Dec 17;10:2936. doi: 10.3389/fimmu.2019.02936

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Copyright © 2019 Toor, Murshed, Al-Dhaheri, Khawar, Abu Nada and Elkord.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Immune checkpoint expression on FoxP3 and Helios subsets in CD4⁺ TILs, PBMC, and NILs. TILs isolated from CRC patients were stained for CD3, CD4, immune checkpoints and FoxP3 and Helios. Representative flow cytometric plots and scatter plots show differences in expression levels of PD-1 (A), CTLA-4 (B), TIM-3 (C), and LAG-3 (D) in CD4⁺FoxP3^−/+Helios^−/+ TILs subsets. Scatter plots show differences in expression levels of PD-1, CTLA-4, and TIM-3 in CD4⁺FoxP3^−/+Helios^−/+ PBMC (E) and NILs (F) from CRC patients. ^***P < 0.001, ^**P < 0.01, ^*P < 0.05.