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. 2019 Dec 17;10:2936. doi: 10.3389/fimmu.2019.02936

Figure 7.

Figure 7

Levels of CD4+ and CD4+CTLA-4+ T cells in CRC patients with different staging and tumor budding. Patients were divided into two groups based on pathologic staging; early stage (Stage I and II) and advanced stage (Stage III and IV). Scatter plots show differences in levels of CD4+ and CD4+CTLA-4+ T cells in PBMC (A), NILs (B), and TILs (C) between CRC patients with early and advanced stages. Patients were also divided into three groups based on degree of tumor budding; low, intermediate and high. Scatter plots show differences in levels of CD4+ T cells in PBMC (D), NILs (E), and TILs (F) between CRC patients. *P < 0.05.