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. 2019 Dec 17;13:1351. doi: 10.3389/fnins.2019.01351

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Copyright © 2019 Ding, Gao, Gao, Meng, Zheng, Dong, Luo, Zhang, Shi and Rong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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G protein-coupled estrogen receptor-mediated rapid calcium rise in SH-SY5Y cells is via the PLC/IP3 pathway. (A–C) The PLC inhibitor U73122 (3 μM) completely blocked the calcium response to E2 (1 μM) and G-1 (1 μM). (D–F) The store calcium release channel (IP3R) blocker, 2-APB, virtually abolished G-1 or E2-evoked calcium responses. The example traces (A,B,D,E) are the average percentage change in fluorescence of 16–25 cells in one visual field. (C,F) The averaged peak percentage changes in fluorescence in different conditions. ^∗∗∗P < 0.001, paired t-test. n = 45∼56 cells from three to four independent tests.