Table 2. Cox regression analysis of DFS for each patient characteristic.
| Characteristics | Univariate | Multivariate | |||
|---|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | ||
| Age | 1.064 (1.042–1.087) | <0.001 | 1.065 (1.042–1.088) | <0.001 | |
| Sex | <0.001 | 0.001 | |||
| Male | 1 | 1 | |||
| Female | 0.303 (0.165–0.558) | 0.362 (0.196–0.668) | |||
| Location | 0.865 | - | |||
| Upper body | 1 | - | |||
| Middle body | 1.268 (0.485–3.312) | - | |||
| Lower body | 1.430 (0.573–3.574) | - | |||
| Size (mm) | 1.012 (1.000–1.024) | 0.047 | 1.008 (0.996–1.021) | 0.196 | |
| Histology | 0.035 | 0.397 | |||
| Differentiated | 1 | 1 | |||
| Undifferentiated | 0.620 (0.398–0.966) | 1.311 (0.700–2.455) | |||
| Lauren classification | 0.022 | 0.138 | |||
| Intestinal | 1 | 1 | |||
| Diffuse | 0.404 (0.224–0.729) | 0.563 (0.251–1.263) | |||
| Others | 1.068 (0.459–2.488) | 1.189 (0.645–2.194) | |||
| pT stage | 0.056 | - | |||
| Mucosa | 1 | - | |||
| Submucosa | 1.525 (0.990–2.349) | - | |||
| No. of resected LN | 0.986 (0.970–1.002) | 0.084 | - | - | |
| No. of metastatic LN | 1.172 (1.101–1.248) | <0.001 | 1.158 (1.091–1.229) | <0.001 | |
| LN metastasis | 0.105 | - | |||
| No | 1 | - | |||
| YES | 1.608 (0.906–2.852) | - | |||
| LVI | 0.024 | 0.348 | |||
| No | 1 | 1 | |||
| Yes | 1.799 (1.080–2.997) | 1.292 (0.757–2.206) | |||
| MSI status | 0.797 | 0.699 | |||
| MSS | 1 | 1 | |||
| MSI-H | 1.107 (0.511–2.398) | 0.855 (0.387–1.890) | |||
DFS = disease-free survival; HR = hazard ratio; CI = confidence interval; LN = lymph node; LVI = lymphovascular invasion; MSI = microsatellite instability; MSS = microsatellite stable; MSI-H = microsatellite instability-high.