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. 2019 Dec 23;115(1):7. doi: 10.1007/s00395-019-0765-7

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Transcriptomic profiles of single CMs in three different ARs: AR1 (square), AR7 (rectangle), and AR11 (elongated). a Boxplot of the number of genes detected in three different morphotypes. The box represents the median, 25% lower and 75% upper percentiles, and the whiskers show the ranges. *p < 0.05, ***p < 0.001 (unpaired Student t test). b Three-dimensional t-SNE projection of 85 patterned CMs of different morphotypes (AR7, n = 31; AR1, n = 28; AR11, n = 26), based on all expressed genes. Different morphotypes are color-coded according to ARs. c PCA plots of 85 patterned, 24 unpatterned and 27 pre-patterned CMs, based on whole-genome expression values. Three principal components corresponding to three largest eigenvalues are shown. d Venn diagrams showing the number of significantly (false discovery rate-adjusted p value < 0.05) downregulated (top panel) and upregulated (bottom panel) genes in different morphotypic comparisons