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. 2019 Dec 17;10:2958. doi: 10.3389/fimmu.2019.02958

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Copyright © 2019 Subauste.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The CD40-ATP-P2X₇ pathway links cellular responses in Müller glia with programmed cell death of bystander retinal endothelial cells in DR. Blood levels of CD154 and expression of CD40 on Müller glia are increased in diabetes. CD40 ligation in Müller glia causes PLCγ1 (PLC)-dependent secretion of extracellular ATP. CD40 ligation in retinal endothelial cells upregulates P2X₇ receptor, making these cells susceptible to P2X₇-induced programmed cell death. Created in part with BioRender.com.