Figure 2.

Midlife is still largely neglected in PD research. (A) Relative publication shares over the past 5 years (2015–2019) examining PD, Alzheimer's disease (AD), Huntington's disease (HD), type II diabetes, and stroke with respect to young, middle, and old age. (B) As in (A) but focusing on PD and AD at greater temporal resolution for the past 10 years. While research on the role of midlife in context of AD is continuously increasing, this trend is less obvious and seemingly lagging behind for PD. Numbers are derived from PubMed searches, querying publication titles and abstracts. For diseases, the terms [parkinson*] for PD, [alzheimer*] for AD, [huntington*] for HD, [maturity-onset diabetes, noninsulin-dependent diabetes mellitus, diabetes mellitus type II, type 2 diabetes mellitus] for type II diabetes, and [ischemic stroke, cerebrovascular accident, cerebral infarction] for stroke were used. For the “young” phase, the terms [adolescen*, youth*, juven*, young adult*, early*life, early adulthood, childhood], for the “middle age” phase, the terms [mid*life, middle*age*, mid*adulthood, middle*adulthood] and for the “old age” phase, the terms [late life, old*age*, senescence, elder*, senior*, geriatr*, aged] were used, respectively.