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. 2019 Dec 17;10:1481. doi: 10.3389/fphys.2019.01481

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Copyright © 2019 Rikard, Athey, Nelson, Christiansen, Lee, Holmes, Peirce and Saucerman.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Key parameters affect spatial gradient of collagen deposition. (A) Sensitivity coefficients calculated based on Equation (11) with individual parameter perturbations of 0.1×. State variable outputs include total collagen area fraction, global semivariance, semivariance in the x direction, and semivariance in the y direction. Collagen area fraction heat maps at 6 weeks with (B) all parameters at baseline, (C) k_gen,IL−1β parameter multiplied by 0.1, and (D) K_d,TGFβ parameter multiplied by 0.1.