Table 2.
Parameters for active and latent TGFβ kinetics.
| Parameter | Description | Equation # | Value | Unit | Citation |
|---|---|---|---|---|---|
| kgen,latentTGFβ | Generation rate of latent TGFβ required to create gradient | 5 | 530,000 | pg/mL*hr | Mass balance constraint |
| ksec,latentTGFβ | Latent TGFβ secreted by fibroblasts | 5 | 23,700 | pg/mL*hr | Wakefield et al., 1987; Campbell and Katwa, 1997; Campaner et al., 2006; Cartledge et al., 2015; Bolívar et al., 2017 |
| kdeg,latentTGFβ | First-order degradation rate for latent TGFβ | 5 | 0.0096 | /hr | Rollins et al., 1989 |
| kact,latentTGFβ | Activation rate of latent TGFβ to active TGFβ | 5 & 6 | 0.045 | Maeda et al., 2002; Hawinkels et al., 2007 |