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. 2019 Dec 23;8:32. doi: 10.1186/s40169-019-0250-9

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© The Author(s) 2019

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The human miR-17-92 gene and its homologs. The gene structure of the human miR-17-92 cluster (located on chromosome 13) and its two mammalian paralogs: the miR-106b-25 cluster (located on human chromosome 7) and the miR-106a-363 cluster (located on the X chromosome). The miRNAs encoded by the 3 clusters are categorized into the miR-17 family (miR-17, miR-20a, miR-106b, miR-93, miR-106a and miR-20b), the miR-18a family (miR-18a and miR-18b), the miR-19 family (miR-19a, miR-19b-1 and miR-19b-2) and the miR-92 family (miR-92a-1, miR-25, miR-92a-2 and miR-363)