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. 2019 Dec 17;10:1321. doi: 10.3389/fneur.2019.01321

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Copyright © 2019 Wang, Wang, Tang, Chen, Dong, Niu, Li, Shi, Shan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative images from patient P2's brain MRI. (a) Axial fluid-attenuated inversion recovery (FLAIR) images show a predominant involvement of the frontal and periventricular areas and deep white matter. (b) The sagittal T1-weighted image shows multiple hypointense lesions in the corpus callosum. (c) Diffusion-weighted imaging (DWI) reveals focal lesions with restricted diffusion in the periventricular white matter. (d) A contrast-enhanced MR angiogram shows the normal appearance of the brain vasculature. (e) MR angiography (MRA) shows a normal cerebral blood vessel. (f) Magnetic resonance spectroscopy (MRS) reveals an inverted lactate peak at 1.33 ppm.