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. 2019 Dec 17;10:1272. doi: 10.3389/fneur.2019.01272

Figure 5.

Figure 5

VPS35-retromer subunit controls the main α-synuclein degradation pathways. VPS35 has a relevant role in controlling the degradation of key molecules in the α-synuclein degradation pathways. In the autophagic process, vacuolar sorting protein 35 (VPS35) interacts and controls the trafficking of Wiskott–Aldrich syndrome protein (WASH) complex (blue) and autophagy-related protein 9A (ATG9A; blue) assuring the correct autophagosome formation; in chaperone-mediated autophagy (CMA), VPS35 controls the retrieval trafficking of lysosome-associated membrane protein 2A (LAMP2A) receptor (light green) to the trans-Golgi Network (TGN); VPS35 interacts with CI-MPR (dark green) and Sortilin (pink) leading indirectly to the trafficking of cathepsin D (CTSD, in red) through early endosomes (EE) and late endosomes (LE). VPS35–D620N mutation and VPS35 deficiency lead to dysfunctions in α-synuclein degradation. Figure was adapted from Servier Medical Art images (http://smart.servier.com/).