Table 1.

Disordered region prediction of proteins targeted by PROTAC.

No.	Target	E3	Potency (DC50)	Disordered region (>40 a.a)	DOI
1	ABL1	CRBN,VHL	100 nM	O	10.1002/anie.201507634
2	AKT	VHL	100–300 nM	X	10.1002/psc.2858
3	ALK	CRBN	10 nM	O	10.1016/j.ejmech.2018.03.071
4	AR	VHL	5 nM	O	10.1038/s42003-018-0105-8
5	BCL6	CRBN	<1 μM	O	10.1021/acschembio.8b00698
6	BCR/ABL	CRBN	0.5–1 μM	O	10.1002/anie.201507634
7	BRD4	CRBN	<10 nM	O	10.1016/j.chembiol.2015.05.009
8	BRD9	CRBN	5–50 nM	O	10.1002/anie.201611281
9	BTK	CRBN	25 nM	O	10.1021/acs.biochem.8b00391
10	CDK4	CRBN	10–100 nM	X	10.1039/c9cc00163h
11	CDK6	CRBN	10–100 nM	X	10.1039/c9cc00163h
12	CDK8	CRBN	~100 nM	O	10.1021/acsmedchemlett.8b00011
13	c-MET	VHL	50 nM	X	10.1016/j.chembiol.2017.09.009
14	CRABP2	cIAP1	~1 μM	X	10.1016/j.febslet.2011.03.019
15	DHODH	VHL	0.1–1 μM	X	10.1002/chem.201702999
16	EGFR	VHL	22.3 nM	O	10.1016/j.chembiol.2017.09.009
17	ER	VHL	1 nM	O	10.1021/acs.jmedchem.8b01572
18	ERK2	CRBN	~1 μM	X	10.1021/acscentsci.6b00280
19	ERRa	VHL	100 nM	O	10.1038/nchembio.1858
20	FAK1	VHL	10 nM	O	10.1021/jacs.8b08008
21	FKBP12	CRBN	<100 nM	X	10.1126/science.aab1433
22	FLT3	VHL	2 nM	X	10.1021/jacs.8b10320
23	GCN5	CRBN	3 nM	O	10.1021/acschembio.8b00705
24	HDAC6	CRBN	100–300 nM	O	10.1016/j.bmcl.2018.05.057
25	HER2	VHL	25–100 nM	O	10.1016/j.chembiol.2017.09.009
26	PCAF	CRBN	1.5 nM	O	10.1021/acschembio.8b00705
27	RIPK2	VHL	1 nM	O	10.1038/nchembio.1858
28	Sirt2	CRBN	~0.5 μM	O	10.1021/acs.jmedchem.6b01872
29	TBK1	VHL	3 nM	X	10.1021/acs.jmedchem.7b00635
30	VHL	VHL	~10 nM	O	10.1038/s41467-017-00954-1

Based on a literature search, PROTACs with high potency (DC₅₀ < 1 μM) were selected, and then analyzed them for a disordered region using the IUPred2A.