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. 2019 Dec 23;9:19696. doi: 10.1038/s41598-019-56051-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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WSB/EiJ mice show differential regulations of circulating leptin levels and metabolic markers under HFD as compared to C57BL/6J strain. Compared analysis of main circulating biomarkers for energetic metabolism and glucose homeostasis in twelve week-old C57BL/6J and WSB/EiJ male mice either maintained under control feeding (CTRL), or challenged with HFD for the last 3 days of the period (3D) or during the whole 8-week experiment duration (8WK). (A) Circulating leptin (in ng/mL; N = 9–12 per group); (B) Adiponectin (in µg/mL; N = 9–11 per group); (C) Resistin (in ng/mL; N = 8–12 per group); (D) C-peptide 2 (in ng/mL; N = 8–12 per group). Graphs represent medians using box and whiskers. Significant differences were indicated by different letters to account for between strain and between diet group differences (P ≤ 0.05; GLM).