Table 1.
Summary table of the statistics (F and p-values) for parameters representative of body composition (related to Fig. 1), circulating lipids (related to Fig. 2), metabolic hormones (related to Fig. 3) and inflammatory hormones (related to Fig. 4)
| Parameter | Strain | Diet | Strain*Diet | Posthoc | ||||
|---|---|---|---|---|---|---|---|---|
| F-value | p-value | F-value | p-value | F-value | p-value | Bl6 CTRL-3D-8WK; WSB CTRL-3D-8WK | ||
| Body composition (Fig. 1) | Final BW | 1894 | <0.0001*** | 8.0 | 0.0005*** | 5.5 | 0.005** | a - ab - b; c - c - c |
| Incremental BW | 5000 | <0.0001*** | 5000 | <0.0001*** | 5000 | <0.0001*** | a - b - c; d - ad - d | |
| % eWAT | 142 | <0.0001*** | 36 | <0.0001*** | 17.9 | <0.0001*** | a - b - c; d - ad - ad | |
| % iWAT | 5.0 | 0.03* | 5.2 | 0.008** | 0.4 | 0.65 | a - ab - ab; ab - b - b | |
| Circulating lipids (Fig. 2) | HDL | 14.3 | 0.0004*** | 48.6 | <0.0001*** | 5.8 | 0.005** | ac - bd - b; a - c - cd |
| Cholesterol | 26.3 | <0.0001*** | 22.3 | <0.0001*** | 6.0 | 0.004** | a - b - b; a - a - a | |
| LDL | 66.8 | <0.0001*** | 18.9 | <0.0001*** | 13.1 | <0.0001*** | a - b - b; a - a - a | |
| Triglycerides | 4.1 | 0.05* | 0.8 | 0.47 | 0.7 | 0.51 | / | |
| VLDL | 4.1 | 0.05* | 0.8 | 0.47 | 0.7 | 0.51 | / | |
| NEFA | 16.5 | 0.0002*** | 0.62 | 0.54 | 0.29 | 0.75 | ab - ab - a; b - ab - ab | |
| Hydroxybotyrate | 189 | <0.0001*** | 5.3 | 0.007** | 6.5 | 0.003** | a - a - a; b - c - bc | |
| Metabolic hormones (Fig. 3) | Leptin | 47.2 | <0.0001*** | 10.2 | 0.0002*** | 12.1 | <0.0001*** | a - bd - b; a - c - ad |
| Adiponectin | 4.6 | 0.04* | 10.1 | 0.0002*** | 0.2 | 0.83 | ab - a - ab; b - a - b | |
| Resistin | 1.7 | 0.20 | 1.0 | 0.37 | 7.8 | 0.001** | a - b - ab; ab - a - ab | |
| C-peptide 2 | 1.5 | 0.23 | 0.7 | 0.49 | 9.7 | 0.0003*** | a - b - ab; b - ab - ab | |
| Inflammatory hormones (Fig. 4) | IFNγ | 243 | <0.0001*** | 1.5 | 0.23 | 2.3 | 0.11 | a - a - a; b - b - b |
| KC/GRO | 68.8 | <0.0001*** | 0.05 | 0.95 | 0.40 | 0.68 | a - a - a; b - b - b | |
| IL-5 | 93.1 | <0.0001*** | 4.7 | 0.01* | 1.2 | 0.31 | a - a - a; b - b - b | |
| IL-10 | 198 | <0.0001*** | 0.52 | 0.60 | 1.0 | 0.37 | a - a - a; b - b - b | |
| IL-6 | 44.3 | <0.0001*** | 0.17 | 0.84 | 0.66 | 0.52 | a - a - a; b - b - b | |
| TNF-α | 1.0 | 0.32 | 0.08 | 0.92 | 0.54 | 0.59 | / | |
| IL-1β | 43.0 | <0.0001*** | 1.2 | 0.32 | 0.18 | 0.84 | ac - a - a; b - bc - b | |
| TAS | 78.7 | <0.0001*** | 1.1 | 0.35 | 0.94 | 0.39 | a - a - a; b - b - b | |
Statistical parametric tests were applied by using linear model (after data transformation when necessary), followed by post-hoc analysis. Analyses were run on all samples as a function of Strain, Diet and Strain*Diet, correcting data to body weight when convenient. Significant differences are indicated by different letters to account for between strains and between diet groups differences.