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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Adv Mater. 2019 Nov 11;31(52):e1905135. doi: 10.1002/adma.201905135

Figure 2. Mass transfer.

Figure 2.

(a) Simulation-predicted oxygen concentration profiles in the BP device, the BP device without the spiral scaffold, and a fully implanted subcutaneous control encapsulating islets. (b) Quantification of spatially averaged islet oxygen concentration (islet number labelled #1 through #8 from left to right). (c) Surface plot of simulation-predicted oxygen profiles in the BP device and a subcutaneously transplanted control encapsulating dispersed (INS-1) cells. (d) Simulation-predicted oxygen concentration in the BP device and a subcutaneously transplanted control along a horizontal cross section (labelled A-A) and a vertical cross section (labelled B-B) from surface plots shown in (c). (e) Schematic of experimental design (top) and microscope images (bottom) of live/dead-stained INS-1 cells in BP device (left) exposed to the atmosphere while partially submerged in media at a pO2 of 24 mmHg and a control alginate slab (right) fully submerged in media at a pO2 of 24 mmHg.