Table IV:
Health related quality of life stratified by best hematologic response to first-line therapy
| PROs at best hematologic response |
Response category |
Number of patients (n) |
Mean score (S.D.) |
Median score (range) |
P-value |
|---|---|---|---|---|---|
| FACT-G Total score | NR | 4 | 62 (26) | 65 (30-89) | |
| PR+VGPR | 16 | 65 (13) | 68 (40-83) | <0.001 | |
| CR | 22 | 83 (20) | 89 (18-108) | ||
| FACT-G PWB score | NR | 5 | 18 (8) | 23 (8-25) | |
| PR+VGPR | 19 | 19 (6) | 17 (6-28) | 0.031 | |
| CR | 26 | 22 (6) | 24 (2-28) | ||
| FACT-G SWB score | NR | 5 | 22 (6) | 23 (13-28) | |
| PR+VGPR | 18 | 20 (6) | 22 (0-27) | 0.029 | |
| CR | 25 | 24 (5) | 26 (7-28) | ||
| FACT-G EWB score | NR | 4 | 16 (4) | 17 (9-19) | |
| PR+VGPR | 17 | 15 (5) | 17 (5-20) | 0.005 | |
| CR | 22 | 19 (5) | 21 (3-24) | ||
| FACT-G FWB score | NR | 4 | 9 (8) | 10 (0-18) | |
| PR+VGPR | 16 | 12 (6) | 12 (3-26) | 0.002 | |
| CR | 22 | 18 (7) | 21 (2-28) |
Abbreviations: PRO: Patient-reported outcome; SD: Standard deviation; FACT-G: Functional Assessment of Cancer Therapy-General; PWB: Physical Well Being; SWB: Social Well Being; EWB: Emotional Well Being; FWB: Functional Well Being; GPH: Global Physical Health; GMH: Global Mental Health; PROMIS: Patient-Reported Outcome Measurement Information System. NR: No Response; PR: Partial Response; VGPR: Very Good Partial Response; CR: Complete Response.