Table 4.

Association between phenotypic features of Sjogren’s Syndrome and menstrual/reproductive history

		Arthritis (702)	UWS (625)	Schirmer's (322)	OSS (666)	Hyper-GG (368)	RF (431)	anti-SSA (489)
		OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)	OR (95%CI)
CES	0	ref	ref	ref	ref	ref	ref	ref
	1	1.2 (1.0–1.5)	1.3 (1.1–1.6)	0.9 (0.7–1.1)	0.8 (0.6–0.9)	0.8 (0.7–1.0)	0.9 (0.8–1.1)	1.0 (0.7–1.0)
	2	1.3 (1.0–1.7)	1.2 (0.9–1.6)	0.9 (0.7–1.2)	0.8 (0.6–1.0)	0.8 (0.6–1.1)	0.9 (0.7–1.1)	0.7 (0.6–1.0)
	3	2.5 (1.3–5.0)	1.1 (0.6–1.8)	1.0 (0.5–1.7)	0.4 (0.2–0.7)	0.3 (0.1–0.8)	0.5 (0.2–0.9)	0.5 (0.3–0.9)
Premenopausal CMC	Q1	ref	ref	ref	ref	ref	ref	ref
	Q2	0.7 (0.5–1.2)	1.8 (1.1–2.8)	0.8 (0.5–1.4)	0.8 (0.5–1.3)	0.9 (0.6–1.5)	0.8 (0.5–1.2)	0.8 (0.5–1.2)
	Q3	0.9 (0.5–1.4)	2.1 (1.3–3.3)	0.9 (0.5–1.5)	0.7 (0.4–1.1)	1.0 (0.6–1.8)	1.0 (0.6–1.7)	0.8 (0.5–1.3)
	Q4	0.7 (0.4–1.2)	3.5 (2.0–6.0)	0.5 (0.3–0.9)	0.6 (0.3–1.0)	0.5 (0.3–0.9)	0.5 (0.3–0.9)	0.5 (0.3–0.9)
	Q5	0.5 (0.2–1.0)	4.1 (2.1–7.9)	0.4 (0.2–0.9)	0.5 (0.3–1.0)	0.5 (0.2–1.0)	0.8 (0.4–1.5)	0.7 (0.4–1.5)
Postmenopausal CMC	Q1	ref	ref	ref	ref	ref	ref	ref
	Q2	0.8 (0.5–1.1)	1.0 (0.7–1.4)	0.7 (0.5–1.1)	0.9 (0.6–1.2)	0.8 (0.5–1.2)	1.0 (0.7–1.5)	1.0 (0.7–1.3)
	Q3	0.7 (0.5–0.9)	1.3 (0.9–1.8)	0.78 (0.5–1.1)	1.1 (0.8–1.6)	0.9 (0.6–1.4)	1.0 (0.7–1.4	0.9 (0.7–1.3)
	Q4	0.6 (0.4–0.9)	1.3 (0.9–1.9)	0.7 (0.5–1.0)	1.1 (0.8–1.5)	0.8 (0.5–1.3)	0.9 (0.6–1.2)	0.8 (0.5–1.1)
	Q5	0.6 (0.4–0.9)	1.5 (1.1–2.2)	0.9 (0.6–1.3)	1.0 (0.7–1.4)	0.8 (0.6–1.3)	0.9 (0.6–1.3)	0.7 (0.5–1.1)

CES: Composite estrogen score; CMC: cumulative menstrual cycling; Q: Quintile; UWS: unstimulated whole salivary flow; OSS: ocular staining score; Hyper-GG: Hypergammaglobulinemia; RF: Rheumatoid Factor