Table.
Characteristics of Patients with T(5;10) Chromosomal Abnormality.
| No. | Diagnosis | Age (years)/ sex |
WBC count (×109/L) | Eos (%) | Immature leukocytes (%) | Cytogenetics | Breakpoint at the CCDC6 | Breakpoint at the PDGFRB | Treatment | Response to imatinib | References (No.) |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | aCML | 49/M | 33 | 6 | 45 | t(5;10)(q33;q22) | exon 7 | exon 11 | HU, Ara-C, 6-TG | NA | 13, 18 |
| 2 | aCML | 48/M | 94 | 7 | NA | t(5;10)(q33;q21.2) | exon 7 | exon 11 | HU, Allo-SCT | NA | 14 |
| 3 | aCML | 44/M | 158 | 8 | 13 | t(5;10)(q33;q22) | exon 7 | exon 11 | Imatinib | CCyR; 3 weeks | 15 |
| 4 | aCML | 49/M | 7.4 | 6 | 5 | t(5;10)(q33;q21) | exon 7 | exon 11 | Imatinib | Failure; 12 weeks | 17 |
| 5 | CMMoL | NA | NA | NA | NA | t(5;10)(q33;q22) | exon 7 | exon 11 | Imatinib | CCyR; 24 months | 16 |
| 6 | aCML | 53/M | 64 | 0.5 | 10 | t(5;10)(q33;q22) | exon 7 | exon 9 | Imatinib | CCyR; 6 months | Present case |
aCML: atypical chronic myeloid leukemia, CMMoL: chronic myelomonocytic leukemia, M: male, WBC: white blood cell. Eos: eosinophil, HU: hydroxyurea, 6-TG: 6-thioguanine, Allo-SCT: allogeneic stem cell transplantation, CCyR: complete cytogenetic response, NA: not applicable