Table 1. Genetic pathways enriched with 47 genes linked to both OCD and ASD.

	Name	# of entities	Overlap	Percent overlap	P-value	Jaccard similarity
2017 updated database	GO: behavior	759	32	4	1.35E-32	0.041344
	GO: regulation of neurotransmitter levels	339	23	6	3.89E-26	0.063361
	GO: synaptic signaling	387	23	5	4.29E-25	0.055961
	GO: trans-synaptic signaling	387	23	5	4.29E-25	0.055961
	GO: cell–cell signaling	741	27	3	4.82E-25	0.03548
	GO: learning or memory	339	22	6	7.56E-25	0.06044
	GO: signaling	815	27	3	4.64E-24	0.032335
	GO: cognition	379	22	5	6.37E-24	0.054455
	GO: regulation of secretion	985	27	2	4.45E-22	0.026866
	GO: regulation of secretion by cell	888	26	2	8.37E-22	0.028603
2019 updated database	GO: behavior	759	26	3	8.44E-24	0.033505
	GO: regulation of neurotransmitter levels	339	21	6	9.71E-24	0.058172
	GO: learning or memory	339	21	6	9.71E-24	0.058172
	GO: regulation of secretion	985	27	2	4.6E-23	0.026973
	GO: cognition	379	21	5	6.26E-23	0.052369
	GO: regulation of secretion by cell	888	26	2	8.1E-23	0.028729
	GO: cell–cell signaling	741	24	3	1.12E-21	0.031579
	GO: signaling	815	24	2	9.14E-21	0.028777
	GO: memory	162	16	9	9.14E-21	0.084656
	GO: synaptic signaling	387	19	4	9.42E-20	0.046229

For each pathway/Go term, the P-value was calculated using Fisher-exact test against the hypothesis that a randomly selected gene group of the same size (47) can generate a same or higher overlap with the corresponding pathway/Go term. All these pathways/Go terms passed the FDR correction (q = 0.05).