TRIMs have an N-terminal RING finger (R), one or two B-boxes (B1 and B2), and coiled coil (CC) domain. C-terminal domains comprise various domains including: ARF, ADP-ribosylation factor family domain; BROMO, bromodomain; COS, cos-box; FIL, filamin-type Ig domain; FN3, fibronectin type III repeat; MATH, meprin and TRAF-homology domain; NHL, NCL1, HT2A and LIN41 domain; PHD, PHD domain; PRY, PRY domain; SPRY, SPRY domain; TM, transmembrane region. Dashed-outline domains are those which are differentially present among subfamily members.