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. 2019 Dec 23;39(12):BSR20192050. doi: 10.1042/BSR20192050

Table 1. TRIM proteins and their roles in regulating neuroblastoma.

TRIM proteins Functions References
TRIM11 Interacting with PHOX2B and increasing the expression of DBH [33]
TRIM16 Enhancing retinoic acid receptor β (RAR-β) transcription [23,43]
Down-regulating cytoplasmic vimentin and nuclear E2F1 [45]
Regulating G1/S cell cycle progression [46]
Modulating activity of caspase-2 and promoting apoptosis [47]
TRIM17 Repressing apoptosis by stabilizing anti-apoptotic proteins Mcl-1 [51,52]
TRIM32 Enhancing transcriptional activity of RARα [63]
Inducing asymmetric cell division (ACD) [64]
Facilitating c-MYC and n-MYC proteasomal degradation [62,64]
TRIM36 Being hypermethylated in neuroblastoma tumors [72]
TRIM59 Inducing the expression of ANXA2 [78]
Regulating Wnt/β-catenin signaling pathway [80]