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Temperature-dependence of non-invasive optical measures of cerebral oxygen extraction fraction, flow, and metabolism during cooling (blue) from normothermia to deep hypothermia, and during rewarming (red) from deep hypothermia back to normothermia. Mean values across subjects (n = 8) are plotted along with standard deviation. Abbreviations: OEF: oxygen extraction fraction; rCBF DCS: DCS measure of relative cerebral blood flow; rCMRO2: relative cerebral metabolic rate of oxygen.
