Figure 4.
(Left) Intracranial temperature hysteresis: significant hysteresis of intracranial temperature (ICT) with respect to nasopharyngeal temperature (NPT) during rewarming (red) versus cooling (blue); rewarming slope p < 0.001, intercept p < 0.001. Non-invasive CMRO2,i Temperature-dependence: (Center) CMRO2,i, with respect to (NPT)−1, also demonstrates significant hysteresis in rewarming slope (p = 0.001) and intercept (p < 0.001). (Right) CMRO2,i, with respect to (ICT)−1, has improved concordance between rewarming versus cooling; rewarming slope p = 0.647, intercept p = 0.585. Thick lines represent fitted linear mixed-effects models; unique symbols connected by thin lines represent individual subject data (n = 8).