Table 3.

Regression Analysis of FMD Primary Outcomes by Sex Subgroup—Linear Contrast With Higher Arm Less Nicotine

	Difference Between Arms in Change	p Value
Change in FMD (+1 group, 1 = TC, 2 = EC-nicotine, 3 = EC-nicotine-free)
Male	0.213 (−0.248 to 0.675)	0.351
Female	1.049 (0.617 to 1.480)	<0.0001
Change in FMD, EC-nicotine-free vs. TC (ref)
Male	0.448 (−0.451 to 1.347)	0.315
Female	2.183 (1.336 to 3.030)	<0.0001
Change in FMD, EC-nicotine vs. TC (ref)
Male	0.822 (−0.067 to 1.710)	0.069
Female	1.824 (0.942 to 2.706)	<0.0001
Change in FMD, EC-nicotine-free vs. EC-nicotine (ref)
Male	−0.374 (−1.239 to 0.492)	0.384
Female	0.359 (−0.449 to 1.167)	0.377

Values are regression coefficient (95% CI).

Adjusted for baseline of the outcome, baseline age (≤40 years, >40 years) and smoking pack-years (≤20 pack-years, >20 pack-years).

Abbreviations as in Tables 1 and 2.