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. 2020 Jan;83:87–111. doi: 10.1016/j.bbi.2019.09.019

Fig. 6.

Fig. 6

Reduced pyruvate metabolism in the hippocampus of APP/PS1 male 4 h after systemic LPS administration. 4.5-month-old male and female APP/PS1 mice and their wild-type (WT) littermates were challenged with LPS (100 µ/kg i.v.) or its vehicle PBS. Schematic representation of the pyruvate metabolic pathway and its links with the sorbitol and glycolate pathways. At 4 h post-injection, LPS-treated APP/PS1 male mice failed to show a reduction in d-sorbitol levels (A), but in contrast, exhibited downregulation of 4 key metabolites of the pyruvate metabolic pathway: 3-Phospho-d-glycerate (B), 2-phosphoglycolate (C), phosphoenolpyruvate (D) and pyruvate (E). Data are expressed as Means ± SEM. Dots represent individual animals. Discriminant metabolites are highlighted by grey text boxes. Pairwise comparisons following 3-way ANOVAs: *, p < 0.05; **, p < 0.01; compared to PBS-treated mice of same sex and genotype. #, p < 0.05; ##, p < 0.01; ###, p < 0.0001; compared to PBS-treated males of same genotype.