Table 1.
Metabolites differently expressed between males and females and in response to LPS. Statistical significance from 3-way ANOVAs followed by pairwise comparisons testing the effect of LPS within each sex, when appropriate. When significant genotype, sex and/or their interaction with treatment were observed, metabolites with VIP values below 1.5 were considered discriminant if pairwise comparisons confirmed genotype or sex differences in PBS-treated mice and/or a sexually dimorphic LPS response.
| Genotype effect (PBS-treated) |
Sex effect (PBS-treated) |
Overall LPS effect |
LPS effect in males |
LPS effect in females |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exact mass | RT (min) | Putative metabolite Formula | Pathway | VIP | p | vs. WT | VIP | p | vs. males | VIP | p | vs. PBS | VIP | p | vs. PBS | VIP | p | vs. PBS |
| Amino acid metabolism | ||||||||||||||||||
| 131.09 | 11.79 | (3R)-beta-Leucine C6H13NO2 |
Valine, leucine and isoleucine degradation | 1.37 | 2.04 | <0.0001 | ↘ | 0.75 | 0.39 | 0.64 | ||||||||
| 103.10 | 15.33 | Choline C5H13NO |
Glycine, serine and threonine metabolism | 0.83 | 0.71 | 1.45 | 2.00 | <0.0001 | ↗ | 0.69 | ||||||||
| 222.07 | 11.11 |
l-cystathionine C7H14N2O4S |
Glycine, serine and threonine metabolism Methionine metabolism |
1.35 | 1.39 | 0.01 | ↘ | 0.89 | 0.65 | 0.88 | ||||||||
| 149.05 | 8.79 |
l-methionine C5H11NO2S |
Methionine metabolism | 0.69 | 0.57 | 2.92 | <0.0001 | ↘ | 2.14 | <0.0001 | ↘ | 1.88 | <0.0001 | ↘ | ||||
| 165.05 | 9.32 |
l-methionine S-oxide C5H11NO3S |
Methionine metabolism | 0.69 | 0.83 | 2.52 | <0.0001 | ↘ | 1.84 | <0.0001 | ↘ | 1.77 | <0.0001 | ↘ | ||||
| 384.12 | 9.50 | S-adenosyl-l-homocysteine C14H20N6O5S |
Methionine metabolism | 0.92 | 1.18 | 0.91 | 1.70 | 0.0001 | ↗ | 1.10 | 0.036 | ↘ | ||||||
| 219.07 | 9.59 | O-succinyl-l-homoserine C14H20N6O5S |
Methionine metabolism | 0.72 | 1.18 | 2.04 | <0.0001 | ↘ | 1.31 | 0.03 | ↘ | 1.50 | <0.0001 | ↘ | ||||
| 398.14 | 11.02 | S-adenosyl-l-methionine C15H22N6O5S |
Methionine metabolism Arginine and proline metabolism |
1.13 | 0.70 | 1.82 | 0.0002 | ↘ | 1.30 | 1.37 | 0.0002 | ↘ | ||||||
| 297.09 | 6.79 | 5′-methylthioadenosine C11H15N5O3S |
Methionine metabolism Arginine and proline metabolism |
1.31 | 1.57 | 0.0001 | ↘ | 2.44 | <0.0001 | ↘ | 2.00 | <0.0001 | ↘ | 1.70 | <0.0001 | ↘ | ||
| 132.05 | 8.62 | N-carbamoylsarcosine C4H8N2O3 |
Arginine and proline metabolism | 0.92 | 1.07 | 1.84 | 0.0002 | ↗ | 1.37 | 0.004 | ↗ | 1.21 | 0.005 | ↗ | ||||
| 231.07 | 8.97 | N-succinyl-l-glutamate 5-semialdehyde C9H13NO6 |
Arginine and proline metabolism | 1.25 | 1.75 | 0.0005 | ↗ | 0.72 | 1.34 | 0.009 | ↗ | 1.37 | 0.005 | ↘ | ||||
| 104.02 | 9.07 | Urea-1-carboxylate C2H4N2O3 |
Arginine and proline metabolism | 1.20 | 0.60 | 1.87 | <0.0001 | ↗ | 1.80 | <0.0001 | ↗ | 1.07 | 0.03 | ↗in WT | ||||
| 188.13 | 16.71 | Homoarginine C7H16N4O2 |
Arginine and proline metabolism | 1.17 | 1.88 | <0.0001 | ↗ | 1.06 | 0.63 | 1.38 | ||||||||
| 133.04 | 10.25 |
l-aspartate C4H7NO4 |
Arginine and proline metabolism Lysine biosynthesis |
1.00 | 1.39 | 1.02 | 1.78 | 0.004 | ↗ | 0.97 | ||||||||
| 276.13 | 10.24 | N6-(l-1,3-Dicarboxypropyl)-l-lysine C11H20N2O6 |
Lysine biosynthesis | 1.16 | 1.52 | 0.002 | ↗ | 0.72 | 0.32 | 0.93 | ||||||||
| 203.08 | 9.24 | N2-acetyl-l-aminoadipate C8H13NO5 |
Lysine biosynthesis | 1.31 | 1.75 | 0.001 | ↗ | 0.90 | 0.75 | 1.14 | ||||||||
| 161.07 | 10.10 |
l-2-aminoadipate C6H11NO4 |
Lysine biosynthesis | 1.44 | 1.69 | 0.008 | ↗ | 0.80 | 1.06 | 0.78 | ||||||||
| 129.08 | 9.34 |
l-pipecolate C6H11NO2 |
Lysine degradation Alkaloid biosynthesis I |
1.38 | 1.65 | <0.0001 | ↘ | 0.91 | 0.86 | 0.79 | ||||||||
| 151.06 | 5.15 | (Z)-4-hydroxyphenylacetaldehyde-oxime C8H9NO2 |
Tyrosine metabolism | 1.28 | 1.85 | <0.0001 | ↘ | 0.82 | 0.97 | 0.57 | ||||||||
| 190.05 | 8.17 | [FA hydroxy,oxo(7:0/2:0)] 4-hydroxy-2-oxo-Heptanedioic acid C7H10O6 |
Tyrosine metabolism | 1.12 | 1.59 | 0.003 | ↗ | 0.91 | 1.30 | 0.03 | ↗ | 1.51 | 0.0002 | ↘ | ||||
| 165.08 | 8.00 |
l-phenylalanine C9H11NO2 |
Phenylalanine, tyrosine and tryptophan biosynthesis | 0.83 | 0.78 | 2.19 | <0.0001 | ↗ | 1.87 | <0.0001 | ↗ | 1.44 | 0.003 | ↗in WT | ||||
| 204.09 | 9.16 |
l-tryptophan C11H12N2O2 |
Phenylalanine, tyrosine and tryptophan biosynthesis Tryptophan metabolism | 1.47 | 1.64 | 0.09 | 2.55 | <0.0001 | ↗ | 1.94 | <0.0001 | ↗ | 1.67 | <0.0001 | ↗ | |||
| 191.06 | 9.66 | 5-hydroxyindoleacetate C10H9NO3 |
Tryptophan metabolism | 1.07 | 0.84 | 2.32 | <0.0001 | ↗ | 2.04 | <0.0001 | ↗ | 1.31 | 0.0012 | ↗ | ||||
| 219.11 | 6.80 | Pantothenate C9H17NO5 |
beta-Alanine metabolism Pantothenate and CoA biosynthesis |
1.27 | 2.06 | 0.0001 | ↗ | 0.75 | 0.93 | 1.16 | ||||||||
| 160.08 | 6.83 |
d-alanyl-d-alanine C6H12N2O3 |
d-Alanine metabolism Peptidoglycan biosynthesis |
1.35 | 0.03 | ↘ | 2.08 | <0.0001 | ↘ | 0.99 | 0.98 | 0.72 | ||||||
| 612.15 | 11.03 | Glutathione disulfide C20H32N6O12S2 |
Glutamate metabolism Glutathione metabolism |
0.82 | 1.37 | 0.77 | 1.51 | 0.001 | ↗ | 1.10 | ||||||||
| 140.06 | 7.25 | Methylimidazoleacetic acid C6H8N2O2 |
Histidine metabolism | 0.97 | 1.40 | 0.88 | 1.51 | 0.002 | ↗ | 1.01 | ||||||||
| 169.08 | 9.39 | N(pi)-methyl-l-histidine C7H11N3O2 |
Histidine metabolism | 1.32 | 2.00 | <0.0001 | ↘ | 1.62 | <0.0001 | ↗ | 1.70 | <0.0001 | ↗ | 1.59 | 0.0005 | ↗ | ||
| 109.02 | 10.64 | Hypotaurine C2H7NO2S |
Taurine and hypotaurine metabolism | 1.43 | 2.07 | <0.0001 | ↘ | 0.95 | 0.87 | 0.95 | ||||||||
| Carbohydrate metabolism | ||||||||||||||||||
| 118.03 | 10.42 | Succinate C4H6O4 |
Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism |
1.14 | 0.65 | 1.69 | 0.0003 | ↘ | 1.40 | 0.005 | ↘ | 1.18 | 0.01 | ↘ | ||||
| 192.03 | 8.66 | Isocitrate C6H8O7 |
Citrate cycle (TCA cycle) Glyoxylate and dicarboxylate metabolism |
1.34 | 1.91 | <0.0001 | ↘ | 0.96 | 1.02 | 0.82 | ||||||||
| 134.02 | 10.92 | (S)-malate C4H6O5 |
Citrate cycle (TCA cycle) Pyruvate metabolism Glyoxylate and dicarboxylate metabolism |
0.97 | 0.82 | 1.46 | 0.79 | 1.53 | 0.0001 | ↘ | ||||||||
| 90.03 | 7.25 | (d)-lactate C3H6O3 |
Pyruvate metabolism | 0.90 | 0.95 | 1.88 | 1.08 | 1.55 | <0.0001 | ↘ | ||||||||
| 379.10 | 9.05 | (d)-S-lactoylglutathione C13H21N3O8S |
Pyruvate metabolism | 0.90 | 0.93 | 1.26 | 0.53 | 1.63 | 0.0008 | ↘ | ||||||||
| 167.98 | 11.75 | Phosphoenolpyruvate C3H5O6P |
Citrate cycle (TCA cycle) Pyruvate metabolism Glycolysis/Gluconeogenesis |
1.08 | 1.48 | <0.0001 | ↗ | 1.23 | 1.79 | 0.01 | ↘ | 0.78 | ||||||
| 88.01 | 6.81 | Pyruvate C3H4O3 |
Citrate cycle (TCA cycle) Glycolysis/Gluconeogenesis |
0.73 | 0.16 | 0.70 | 1.66 | 0.03 | ↘ | 0.53 | ||||||||
| 170.00 | 10.31 |
d-glyceraldehyde 3-phosphate C3H7O6P |
Glycolysis/Gluconeogenesis | 0.87 | 0.33 | 1.70 | 0.0007 | ↘ | 1.10 | 0.04 | ↘in APP/PS1 | 1.28 | 0.003 | ↘in APP/PS1 | ||||
| 185.99 | 11.39 | 3-phospho-d-glycerate C3H7O7P |
Glycolysis/Gluconeogenesis Glyoxylate and dicarboxylate metabolism |
0.99 | 1.35 | <0.0001 | ↗ | 1.10 | 1.69 | 0.007 | ↘ | 0.67 | ||||||
| 155.98 | 11.41 | 2-phosphoglycolate C2H5O6P |
Glyoxolate and dicatboxylate metabolism | 1.28 | 2.11 | <0.0001 | ↘ | 1.08 | 1.54 | 0.0007 | ↘ | 0.71 | ||||||
| 206.01 | 11.83 | 3-oxalomalate C6H6O8 |
Glyoxolate and dicatboxylate metabolism | 1.28 | 2.00 | <0.0001 | ↘ | 0.85 | 0.91 | 0.61 | ||||||||
| 164.07 | 9.24 |
l-rhamnose C6H12O5 |
Fructose and mannose metabolism | 0.99 | 0.78 | 1.16 | 1.51 | 0.002 | ↗ | 0.85 | ||||||||
| 182.08 | 10.09 |
d-sorbitol C6H14O6 |
Fructose and mannose metabolism | 1.07 | 0.96 | 2.06 | <0.0001 | ↘ | 1.40 | 0.002 | ↘in WT | 1.65 | <0.0001 | ↘ | ||||
| 276.02 | 11.62 | 6-phospho-d-gluconate C6H13O10P |
Pentose phosphate pathway | 0.79 | 0.86 | 1.70 | 0.0006 | ↘ | 1.07 | 0.08 | 1.33 | 0.001 | ↘ | |||||
| 154.00 | 8.48 | Propanoyl phosphate C6H13O10P |
Propanoate metabolism C5-Branched dibasic acid metabolism |
1.05 | 0.85 | 0.98 | 1.53 | 0.0009 | ↗ | 0.64 | ||||||||
| 130.03 | 8.65 | Itaconate C5H6O4 |
C5-Branched dibasic acid metabolism Citrate cycle (TCA cycle) |
1.34 | 1.91 | <0.0001 | ↘ | 0.94 | 1.10 | 0.74 | ||||||||
| 146.02 | 9.93 | Methyloxaloacetate C5H6O5 |
C5-Branched dibasic acid metabolism | 1.20 | 1.53 | 0.006 | ↘ | 0.95 | 0.88 | 0.94 | ||||||||
| Nucleotide metabolism | ||||||||||||||||||
| 136.04 | 8.58 | Hypoxanthine C5H4N4O |
Purine metabolism | 0.77 | 0.78 | 1.00 | 1.66 | 0.03 | ↗ | 0.94 | ||||||||
| 168.03 | 9.07 | Urate C5H4N4O3 |
Purine metabolism | 0.22 | 0.59 | 2.17 | <0.0001 | ↗ | 1.77 | <0.0001 | ↗ | 1.34 | 0.006 | ↗ | ||||
| 463.07 | 11.88 | N6-(1,2-Dicarboxyethyl)-AMP C14H18N5O11P |
Purine metabolism | 0.85 | 0.71 | 1.52 | 0.69 | 1.52 | <0.0001 | ↘ | ||||||||
| 156.02 | 7.91 | Orotate C5H4N2O4 |
Pyrimidine metabolism | 1.21 | 1.58 | 0.005 | ↗ | 0.83 | 1.08 | 1.18 | 0.01 | ↘ | ||||||
| 242.09 | 6.82 | Thymidine C10H14N2O5 |
Pyrimidine metabolism | 0.57 | 0.26 | 2.05 | <0.0001 | ↗ | 1.88 | 0.002 | ↗ | 1.18 | 0.0007 | ↗ | ||||
| 126.04 | 6.82 | Thymine C5H6N2O2 |
Pyrimidine metabolism | 0.74 | 0.98 | 1.87 | <0.0001 | ↗ | 1.77 | 0.002 | ↗ | 1.03 | 0.005 | ↗ | ||||
| 114.04 | 7.17 | 5,6-dihydrouracil C4H6N2O2 |
Pyrimidine metabolism Beta-Alanine metabolism Pantothenate and CoA biosynthesis |
0.70 | 0.88 | 0.77 | 1.52 | 0.0007 | ↗ | 0.93 | ||||||||
| Lipid metabolism and Fatty acyls | ||||||||||||||||||
| 284.27 | 3.88 | Octadecanoic acid C18H36O2 |
Fatty acids biosynthesis Biosynthesis of unsaturated fatty acids |
1.13 | 0.99 | 1.50 | 0.004 | ↘in WT | 0.89 | 1.46 | 0.005 | ↘ | ||||||
| 256.24 | 3.91 | Hexadecanoic acid C16H32O2 |
Biosynthesis of unsaturated fatty acids | 1.21 | 1.18 | 1.52 | 0.002 | ↘ | 0.92 | 1.35 | 0.01 | ↘ | ||||||
| 306.25 | 3.88 | Icosatrienoic acid C20H34O2 |
Biosynthesis of unsaturated fatty acids | 0.70 | 094 | 0.88 | 0.57 | 1.41 | 0.001 | ↘ | ||||||||
| 304.24 | 3.88 | [FA (20:4)] 5Z,8Z,11Z,14Z-eicosatetraenoic acid C20H32O2 |
Fatty Acids and Conjugates | 0.96 | 0.85 | 1.32 | 0.42 | 1.62 | <0.0001 | ↘ | ||||||||
| 118.06 | 5.16 | Formyl 3-hydroxy-butanoate C5H10O3 |
Fatty esters | 1.44 | 2.17 | <0.0001 | ↘ | 0.97 | 1.16 | 0.88 | ||||||||
| 172.01 | 10.13 |
sn-glycerol 3-phosphate C3H9O6P |
Glycerolipid metabolism Glycerophospholipid metabolism |
0.99 | 1.34 | 0.98 | 0.76 | 1.33 | 0.0009 | ↘ | ||||||||
| 306.26 | 3.88 |
sn-glycero-3-Phosphoethanolamine C5H14NO6P |
Glycerophospholipid metabolism Ether lipid metabolism |
1.26 | 1.37 | 1.79 | 0.47 | 1.69 | <0.0001 | ↘ | ||||||||
| 393.29 | 4.82 | PGH2-EA C23H39NO4 |
Eicosanoids | 1.11 | 1.05 | 1.73 | 0.0003 | ↗ | 1.40 | 0.01 | ↗ | 1.18 | 0.005 | ↗ | ||||
| Energy Metabolism | ||||||||||||||||||
| 506.99 | 10.98 | ATP C10H16N5O13P3 |
Oxidative phosphorylation Purine metabolism |
1.04 | 0.80 | 1.97 | <0.0001 | ↘ | 1.47 | 0.002 | ↘ | 1.28 | 0.0004 | ↘ | ||||
| 340.00 | 11.91 |
d-fructose 1,6-bisphosphate C6H14O12P2 |
Carbon fixation | 1.04 | 1.54 | 0.002 | ↗ | 1.44 | 0.0005 | ↘ | 1.15 | 0.05 | ↘ | 1.21 | 0.003 | ↘ | ||
| 370.01 | 12.01 |
d-sedoheptulose 1,7-bisphosphate C7H16O13P2 |
Carbon fixation | 1.23 | 1.22 | 1.32 | 0.81 | 1.52 | <0.0001 | ↘ | ||||||||
| Metabolism of Cofactors and Vitamins | ||||||||||||||||||
| 73.02 | 10.25 | Iminoglycine C2H3NO2 |
Thiamine metabolism | 0.71 | 0.98 | 1.00 | 1.56 | 0.001 | ↗ | 0.91 | ||||||||
| 152.06 | 6.87 | N1-methyl-2-pyridone-5-carboxamide C7H8N2O2 |
Nicotinate and nicotinamide metabolism | 0.81 | 0.61 | 2.73 | <0.0001 | ↗ | 2.25 | <0.0001 | ↗ | 1.62 | <0.0001 | ↗ | ||||
| Peptides | ||||||||||||||||||
| 276.10 | 11.03 | Gamma glutamylglutamic acid C10H16N2O7 |
Peptide | 0.95 | 0.94 | 0.89 | 1.59 | 0.005 | ↗ | 0.90 | ||||||||
| 262.08 | 9.71 |
l-beta-aspartyl-l-glutamicacid C9H14N2O7 |
Peptide | 1.52 | 0.03 | ↘in ♀ | 0.82 | 0.65 | 0.56 | 0.58 | ||||||||
| 357.13 | 7.80 | Asp-Ser-His C13H19N5O7 |
Basic peptide | 0.71 | 0.74 | 1.54 | 0.005 | ↘ | 0.82 | 1.36 | 0.002 | ↘ | ||||||
| 508.18 | 6.81 | Asn-Met-Met-Asn C18H32N6O7S2 |
Hydrophobic peptide | 0.52 | 1.01 | 1.60 | 1.57 | 0.003 | ↘ | 0.95 | ||||||||
| 482.20 | 8.23 | Asp-Phe-Thr-Thr C21H30N4O9 |
Hydrophobic peptide | 1.34 | 0.03 | ↗in ♂ | 1.59 | 0.003 | ↗ | 0.86 | 0.69 | 0.64 | ||||||
| 360.14 | 8.79 | Asn-Asn-Asn C12H20N6O7 |
Polar peptide | 0.72 | 0.15 | 2.87 | <0.0001 | ↘ | 2.10 | <0.0001 | ↘ | 1.85 | <0.0001 | ↘ | ||||
| Biosynthesis of Polyketides and nonribosomal Peptides | ||||||||||||||||||
| 509.33 | 4.64 | Narbomycin C28H47NO7 |
Biosynthesis of 12-, 14- and 16-membered macrolides | 0.61 | 0.29 | 2.14 | <0.0001 | ↗ | 1.44 | 0.003 | ↗ | 1.50 | <0.0001 | ↗ | ||||
| 515.18 | 11.20 | 13-dihydrocarminomycin C26H29NO10 |
Biosynthesis of type II polyketide products | 1.21 | 1.71 | 0.004 | ↗ | 0.84 | 0.86 | 0.69 | ||||||||
| Biosynthesis of Secondary metabolites | ||||||||||||||||||
| 200.08 | 7.89 | Dihydroclavaminic acid C8H12N2O4 |
Clavulanic acid biosynthesis | 1.27 | 2.04 | <0.0001 | ↘ | 0.80 | 0.79 | 0.83 | ||||||||
| Not known | ||||||||||||||||||
| 102.08 | 16.19 | γ-aminobutyramide C4H10N2O |
N known | 1.23 | 1.73 | 0.004 | ↗ | 0.77 | 1.48 | 0.003 | ↗ | 1.37 | 0.006 | ↘ | ||||
| 274.05 | 10.27 | 1-deoxy-d-altro-heptulose 7-phosphate C7H15O9P |
Not known | 1.13 | 1.19 | 1.24 | 1.65 | 0.01 | ↗ | 0.58 | ||||||||
| 281.11 | 10.68 | 1-methyladenosine C11H15N5O4 |
Not known | 1.54 | 0.03 | ↗in ♀ | 0.61 | 0.1 | 0.79 | 0.53 | ||||||||
| 367.27 | 4.95 | 3,5-tetradecadiencarnitine C21H37NO4 |
Not known | 1.06 | 1.24 | 1.57 | 0.002 | ↗ | 1.15 | 0.01 | ↗ | 1.44 | 0.04 | ↗ | ||||
| 181.99 | 9.73 | 3-methylphosphoenolpyruvate C4H7O6P |
Not known | 1.20 | 1.77 | <0.0001 | ↘ | 0.88 | 0.75 | 0.83 | ||||||||
| 181.10 | 8.58 | 6-methyltetrahydropterin C7H11N5O |
Not known | 1.00 | 1.11 | 0.83 | 1.79 | 0.0006 | ↗ | 1.05 | 0.02 | ↘ | ||||||
| 430.20 | 5.36 | Athamantin C24H30O7 |
Not known | 1.31 | 1.79 | 0.01 | ↗ | 0.85 | 0.78 | 0.65 | ||||||||
| 348.11 | 9.24 | Camptothecin C20H16N2O4 |
Not known | 0.97 | 0.72 | 1.59 | 0.02 | ↘ | 1.37 | 0.009 | ↘in WT | 1.11 | ||||||
| 158.06 | 4.39 | Dimethyl citraconate C7H10O4 |
Not known | 0.97 | 1.72 | 0.0005 | ↘ | 0.53 | 0.92 | 1.11 | ||||||||
| 159.13 | 9.46 |
dL-2-sulfoctanoicacid C8H17NO2 |
Not known | 1.09 | 1.67 | 0.0002 | ↗ | 0.60 | 0.41 | 0.88 | ||||||||
| 425.35 | 4.65 | Elaidiccarnitine C25H47NO4 |
Not known | 1.20 | 1.44 | 1.53 | 0.004 | ↗ | 1.19 | 0.04 | ↗in APP/PS1 | 1.14 | 0.03 | ↗in WT | ||||
| 275.14 | 8.59 | Glutarylcarnitine C12H21NO6 |
Not known | 1.36 | 1.89 | 0.007 | ↗ | 0.68 | 0.70 | 0.87 | ||||||||
| 246.05 | 8.65 | Glycerophosphoglycerol C6H15O8P |
Not known | 1.28 | 1.52 | 0.003 | ↗ | 1.29 | 0.68 | 1.49 | 0.0001 | ↘ | ||||||
| 423.33 | 4.68 | Linoelaidylcarnitine C25H45NO4 |
Not known | 1.28 | 1.42 | 1.52 | 0.003 | ↗ | 1.24 | 0.02 | ↗ | 0.98 | 0.04 | ↗ | ||||
| 216.12 | 10.34 | N-acetyl-(l)-arginine C8H16N4O3 |
Not known | 1.15 | 0.03 | ↘in ♀ | 1.53 | 0.005 | ↗ | 0.87 | 0.76 | 1.28 | 0.0008 | ↘ | ||||
| 202.14 | 14.08 | NG,NG-dimethyl-l-arginine C8H18N4O2 |
Not known | 1.22 | 0.97 | 1.32 | 1.60 | 0.001 | ↗ | 0.81 | ||||||||
| 243.09 | 8.89 | Nocardicin C C23H26N4O8 |
Not known | 0.91 | 0.71 | 1.65 | 0.71 | 1.53 | <0.0001 | ↘ | ||||||||
| 175.03 | 5.16 | Nonulose 9-phosphate C9H19O12P |
Not known | 1.15 | 1.48 | 0.004 | ↘ | 1.81 | 1.91 | <0.0001 | ↘ | 0.70 | ||||||
| 249.03 | 12.35 | Norepinephrinesulfate C8H11NO6S |
Not known | 0.97 | 1.87 | 0.003 | ↗ | 0.75 | 1.35 | 0.008 | ↗ | 0.72 | ||||||
| 288.06 | 8.85 | Orotidine C10H12N2O8 |
Not known | 1.29 | 1.56 | 0.0003 | ↗ | 0.92 | 0.59 | 1.19 | 0.007 | ↘ | ||||||
| 371.30 | 4.84 | Tetradecanoylcarnitine C21H41NO4 |
Not known | 1.22 | 1.53 | 0.04 | ↘ | 1.00 | 0.90 | 0.77 | ||||||||
| 573.09 | 8.83 | GDP-3,6-dideoxy-d-galactose C16H25N5O14P2 |
Not known | 1.17 | 0.81 | 1.10 | 1.79 | 0.002 | ↗ | 0.63 | ||||||||
| 133.07 | 6.76 | N-hydroxyvaline C5H11NO3 |
Linamarin biosynthesis | 1.29 | 1.70 | <0.0001 | ↘ | 2.45 | <0.0001 | ↘ | 2.14 | <0.0001 | ↘ | 1.61 | <0.0001 | ↘ | ||
PBS: Phosphate-buffered saline; WT: wild-type; ♀: female; ♂: male.