Table 2.
List of activities of peptides annotated in the BIOPEP-UWM database of bioactive peptides.
| Activity | Description 1 |
|---|---|
| ACE inhibitor 2 | Inhibitors of angiotensin-converting enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) |
| activating ubiquitin-mediated proteolysis | Peptides activating proteolysis mediated by ubiquitin |
| alpha-amylase inhibitor 2 | Inhibitors of α-amylase (EC 3.2.1.1) |
| alpha-glucosidase inhibitor 2 | Inhibitors of α-glucosidase (EC 3.2.1.20) |
| anorectic | Peptides causing a decrease in food intake and suppression of appetite. |
| antiamnestic | Inhibitors of prolyl oligopeptidase (EC 3.4.21.26) (MEROPS ID: S09.001). The enzyme catalyzes degradation of neuropeptides, e.g., involved in processes associated with memory. |
| antibacterial | Peptides revealing any action against bacteria |
| anticancer | Peptides revealing any action against cancers |
| antifungal | Peptides revealing any action against fungi |
| anti-inflammatory | Peptides reducing inflammation or swelling |
| antioxidative | Peptides inhibiting oxidation |
| antithrombotic | Inhibitors of blood coagulation. Inhibitors of thrombin (EC 3.4.21.5) (MEROPS ID: S01.217) are attributed to this activity. |
| antiviral | Peptides revealing any action against viruses. Inhibitors of viral enzymes are included. |
| bacterial permease ligand | Ligands of bacterial permeases |
| binding 2 | Peptides binding any biomolecules. Mineral binding peptides are also attributed to this activity. |
| CaMKII inhibitor 2 | Inhibitors of Ca2+/calmodulin-dependent protein kinase (CaMKII) (EC 2.7.11.17) |
| CaMPDE inhibitor 2 | Inhibitors of 3′,5′-cyclic-nucleotide phosphodiesterase (Calmodulin-dependent phosphodiesterase 1—CaMPDE) (EC 3.1.4.17) |
| chemotactic | Peptides inducing chemotaxis, i.e. movement in response to a chemical stimulus |
| celiac toxic | Peptides toxic to people suffering from celiac disease |
| contracting | Peptides stimulating muscle contraction |
| dipeptidyl peptidase III inhibitor 2 | Inhibitors of dipeptidyl peptidase III (EC 3.4.14.4) (MEROPS ID M49.001) |
| dipeptidyl peptidase IV inhibitor 2 | Inhibitors of dipeptidyl peptidase IV (EC 3.4.14.5) (MEROPS ID S09.003) |
| embryotoxic | Peptides toxic to animal embryos |
| hemolytic | Peptides destroying red blood cells |
| heparin binding 2 | Heparin binding peptides |
| HMG-CoA reductase inhibitor 2 | Inhibitors of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase) (EC 1.1.1.34) |
| hypotensive | Peptides causing blood pressure decrease |
| immunomodulating | Peptides modulating activity of the immune system |
| immunostimulating | Peptides stimulating activity of the immune system |
| inhibitor 2 | Peptides inhibiting various biological processes. Information about processes is provided on the pages of individual peptides. |
| membrane-active 2 | Peptides affecting transmembrane transport |
| natriuretic | Peptides inducing the excretion of sodium by kidneys (natriuresis) |
| neuropeptide | Peptides affecting activity of the nervous system |
| opioid | Ligands of opioid receptors |
| opioid agonist | Agonists of opioid receptors |
| opioid antagonist | Antagonists of opioid receptors |
| orphan receptor GPR14 agonist | Agonists of orphan receptor GPR14 |
| Protein Kinase C inhibitor 2 | Inhibitors of protein kinase C (EC 2.7.11.13) |
| regulating | Peptides regulating various biological processes. Information about processes is provided on the pages of individual peptides. |
| renin inhibitor 2 | Inhibitors of renin (EC 3.4.23.15) (MEROPS ID A01.007) |
| stimulating | Peptides stimulating various biological processes. Information about processes is provided on the pages of individual peptides. |
| toxic 2 | Toxic peptides |
| vasoconstrictor | Peptides causing blood pressure increase |
1 More information concerning enzymes inhibited by peptides is available in the following databases: ExplorEnz [38], BRENDA [39], ChEMBL [40], and MEROPS [41]. Information about associations between abnormal enzyme activity and diseases may be found in the OpenTargets database [42]. 2 Activities absent in the version described in our publication from 2008 [8].