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Drugs targeting the three pathways involved in the pathogenesis of pulmonary arterial hypertension. eNOS, endothelial nitric oxide synthase; PGI2, prostaglandin I2; NO, nitric oxide; ET-1, endothelin-1; IP, prostaglandin I2 receptor; ETA, endothelin type A receptor; ETB, endothelin type B receptor; ATP, adenosine triphosphate; cAMP, cyclic adenosine monophosphate; GTP guanosine triphosphate; cGMP, cyclic guanosine monophosphate; PDE5, phosphodiesterase type 5.
