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. 2019 Nov 21;20(23):5845. doi: 10.3390/ijms20235845

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Expression of Endothelin-1 (ET-1), brain natriuretic peptide (BNP), and transforming growth factor-beta 1 (TGF-β1) in myocardial tissues after ventricular arrhythmia (VA). (A,B) BNP, ET-1, and TGF-β1 protein expression in myocardial tissues of rats after VA by western blot. (C) Expression of BNP mRNA (Nppb) and ET-1 mRNA (Edn1) in left ventricular myocardial tissues of rats after VA by real-time quantitative polymerase chain reaction (qPCR). (D) Correlation of left ventricular end-diastolic pressure (LVEDP) with Nppb and Edn1. The mean value of each indicator in the 0 min subgroup of the BaCl₂ group was set as 100%. (E) Immunohistochemical (IHC) staining for BNP and ET-1 expression in rat myocardium of the BaCl₂ subgroup. * p < 0.05, BaCl₂ group vs. saline group in the same time subgroup. # p < 0.05, different time subgroups vs. 0 min subgroup in the BaCl₂ group.